Distant intercellular interactions in a system of two tissue cultures.

V.P. Kaznacheef, S.P. Shurin, L.P. Mikhailova, and N.V. Ignatovish

State Medical School, Novossibirsk, U.S.S.R., and School of Automatics and Electrometrics, Novossibirsk, U.S.S.R.

Data is presented regarding distant interactions of the cells in two tissue cultures, one of which was infected by a toxic external agent. The two cultures were placed in isolated containers which preserved optical contact through quartz windows. The interaction between cultures was determined by the cytopathic effect (i.e. number of cells killed) in each culture. When specified conditions were met, a "mirror" cytopathic effect was observed in the tissue culture not exposed to the toxic agent. This "mirror" effect  (or "cross-infection") may be due to INFORMATION transmitted from one tissue culture to the other by means of biochemiluminescent "CODE".

(note "INFORMATION" and "CODE")